Glycyrrhiza glabra Linn. (Family: Fabaceae) is a traditional medicinal plant used in various ancient medicine systems and documented across the globe for its ethnopharmacological value to cure varieties of ailments. Glycyrrhizin is the major active constituent obtained from licorice roots, one of the most widely used in herbal preparations for the treatment and management of chronic diseases. The present mini-review is focused mainly on major secondary metabolites, ethnopharmacology, and potential medicinal uses of Glycyrrhiza glabra. Reported pharmacological activities, characterized secondary metabolites and traditional uses of Glycyrrhiza glabra warrants its potential therapeutic